| ncRNA name | CTGF shRNA |
| ncRNA Category | shRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Rattus norvegicus |
| Tissues/Cell_line | retinas |
| Methods | shRNA knockdown, qPCR, transmission electron microscopy, immunofluorescence, fluorescence microscopy |
| Expression pattern | associated |
| Functional description | Anti-VEGF treatment alone may cause up-regulation of connective tissue growth factor (CTGF) in the retina, increasing the risk of fibrosis and tractional retinal detachment. Ranibizumab significantly lowered VEGF but elevated CTGF mRNA, whereas CTGF shRNA significantly reduced the mRNA levels of both CTGF and VEGF in diabetic retinas. |
| PubMed ID | 24451141 |
| Year | 2014 |
| Title | Intravitreal injection of ranibizumab and CTGF shRNA improves retinal gene expression and microvessel ultrastructure in a rodent model of diabetes. |
| Drug-related ncRNA | NA |
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